Novel blood compatible polyurethanes containing long‐chain alkyl groups and phosphatidylcholine analogues

A series of new amphiphilic polyurethanes containing long‐chain alkyl groups as hydrophobic part and phosphatidylcholine analogues as hydrophilic part in the side chains was synthesized and characterized by their IR and 1H NMR spectral data and elemental analyses. The detailed studies for polyurethane 7b show that no evidence of any blood platelet attachment was apparent from the platelet rich plasma (PRP) contact studies and by scanning electron microscopy (SEM) evaluation for the synthesized polyurethane. Moreover, it quickly forms a gel in chloroform, N,N‐dimethylformamide, dimethyl sulfoxide and even to some extent in water. Preliminary studies suggest that these new polyurethanes are very interesting due to their excellent blood compatibilities and prospective importance for biomedical applications.