Stability of Amoxycillin, Clindamycin and Meropenem in Peritoneal Dialysis Solution

Aim To determine the stability of amoxycillin, clindamycin and meropenem in peritoneal dialysis solution containing glucose 2.5% at 37 °C over 6 hours. Method A stability‐indicating high‐performance liquid chromatography assay was used to determine the concentration of amoxycillin, clindamycin and meropenem in peritoneal dialysis solution (Dianeal PD‐4). Antibiotic solutions (amoxycillin 1 g, clindamycin 300 mg, meropenem 1 g) were prepared in 2 L peritoneal dialysis bags and stored at 37 °C. These were analysed at 0, 3 and 6 hours. A degradation profile was constructed for each antibiotic using linear regression and concentration remaining at 6 hours was calculated. Results Clindamycin and meropenem retained at least 90% or greater of the original concentration in the peritoneal dialysis solution over 6 hours, while amoxycillin displayed marginal stability. Conclusion Clindamycin and meropenem are stable for 6 hours in peritoneal dialysis solution containing 2.5% glucose. Amoxycillin's stability was marginal, which could be improved with a modified formulation.