The effects of 13 fungal toxins (and one derivative) on the larvae of zebra fish, Brachydanio rerio (Hamilton-Buchanan), were investigated. The most toxic were sterigmatocystin, gliotoxin, and aflatoxin B1, which were lethal at concentrations of less than 1 µg/ml. Aflatoxins B2, G1, and G2, stemphone, diacetoxyscirpenol, ochratoxin A, aspertoxin, and patulin also showed toxicity to the larvae, while aflatoxin B1 hemiacetal, penicillic acid, and griseofulvin were non-toxic at the levels tested. Specific morphological effects were noted with sterigmatocystin, aflatoxins, and stemphone. The usefulness of zebra fish larvae as bioassay test organisms for fungal toxins is discussed.
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Abedi et al. (1969) studied this question.