A conical glass nanopore was first modified with ultrathin gold nanofilm via a simple and innovative chemical reduction of HAuCl4 on a surface-attached poly(L-histidine) monolayer in the presence of a mild reductant, NH2OH·HCl, followed by surface functionalization with 2-thiouracil, and exploited for the selective nonenzymatic detection of uric acid and especially for serum sample detection.
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He et al. (2014) studied this question.
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