Enhanced allostimulatory activity of host antigen-presenting cells in old mice intensifies acute graft-versus-host disease

Methods BMT.Female C57BL/6 (B6, H-2 b , CD45.2 + ), B6D2F1 (H-2 b/d , CD45.2 + ), B6SJLF1 (H-2 b/s ), B10.BR (H-2 k/k ), and CBA (H-2 k/k ) mice were purchased from The Jackson Laboratory (Bar Harbor, Maine, USA).B6.Ly5.2 (H-2 b , CD45.1 + ) mice were purchased from Frederick Cancer Research Facility (Frederick, Maryland, USA).Mice were transplanted according to a standard protocol