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A simple, high-yielding synthesis of 2,4,5-trisubstituted imidazoles from 1,2-diketone/1,2-hydroxyketone and aldehydes in the presence of NH4OAc is described. Under solvent-free conditions, aryl and heteroaryl substituted imidazoles are formed in yields ranging from 70 to 90%.
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Heravı et al. (2011) studied this question.
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