The asymmetric Juliá–Colonna epoxidation reaction under triphasic/PTC conditions has been successfully scaled‐up to a one‐hundred gram substrate level providing the corresponding epoxy ketone with high optical purity (up to 97% ee) and in good yield (75–78%). The amount of polyamino acid catalyst could be reduced leading to a simplified reaction work‐up. In order to minimise the overall reaction time baffled reactors with pitched‐blade impellers have been employed.
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Gerlach et al. (2004) studied this question.
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