Study of Total Red Cell Volume and Erythrocyte Survival Using Radioactive Chromium in Patients With Advanced Pulmonary Tuberculosis

Article1 April 1955STUDY OF TOTAL RED CELL VOLUME AND ERYTHROCYTE SURVIVAL USING RADIOACTIVE CHROMIUM IN PATIENTS WITH ADVANCED PULMONARY TUBERCULOSISJAMES W. HOLLINGSWORTH, DOROTHY R. HOLLINGSWORTH, M.D.JAMES W. HOLLINGSWORTHSearch for more papers by this author, DOROTHY R. HOLLINGSWORTH, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-42-4-810 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptRadioactive chromium in sodium chromate is adsorbed firmly on the hemoglobin of intact red cells, thereby tagging the cells. Such red cells were used by Sterling and Gray to measure total red cell volume,1 and by Ebaugh, Emerson and Ross to study the survival of erythrocytes in vivo.2In the past, the hemolytic element of the anemia of chronic infections has been investigated only by the measurement of pigment excretion, which was found to be normal.3No studies of erythrocyte lifespan in patients with tuberculosis have been reported. Berlin4has measured red cell volume in patients with tuberculosis, using radioactive...Bibliography1. SterlingGray KSJ: Determination of the circulating red cell volume in man by radioactive chromium, J. Clin. Investigation 29: 1614, 1950. CrossrefMedlineGoogle Scholar2. EbaughEmersonRoss FOCPJF: The use of radioactive chromium 51 as an erythrocyte tagging agent for the determination of red cell survival in vivo, J. Clin. Investigation 32: 1260, 1953. CrossrefMedlineGoogle Scholar3. Wintrobe MM: Clinical hematology, 1952, Lea and Febiger, Philadelphia, p. 546. Google Scholar4. BerlinRawlesHydeParsonsLawrencePort NDFGMRJJHS: Blood volume in pulmonary tuberculosis, Arch. Int. Med. 88: 17, 1951. CrossrefGoogle Scholar5. von Porat BT: Blood volume determinations with the Evans blue dye method, Acta med. Scandinav., Supp. 256, 140: 1951. Google Scholar6. NechelesWeinsteinLeRoy TFIMG: Radioactive sodium chromate for the study of survival of red blood cells. I. The effect of radioactive sodium chromate on red cells, J. Lab. and Clin. Med. 42: 358, 1953. MedlineGoogle Scholar7. SutherlandMcCallGrovesMuirhead DAMSMEE: The survival of human erythrocytes estimated by means of cells tagged with radioactive chromium: a study of the normal state, J. Lab. and Clin. Med. 43: 717, 1954. MedlineGoogle Scholar8. BerlinHydeParsonsLawrence NIGMRJJH: The blood volume in various medical and surgical conditions, New England J. Med. 247: 675, 1952. CrossrefMedlineGoogle Scholar9. HenschelMichelsonTaylorKeys AAHLA: Plasma volume and thiocyanate space in famine edema and recovery, Am. J. Physiol. 150: 170, 1947. CrossrefMedlineGoogle Scholar10. Mollison PL: Observations on cases of starvation at Belsen, Brit. M. J. 1: 4, 1946. CrossrefGoogle Scholar11. WaltersRossiterLehmann JHRJH: Blood volume changes in protein deficiency, Lancet 1: 244, 1947. CrossrefMedlineGoogle Scholar12. CallenderPowellWitts STEOLJ: Normal red cell survival in men and women, J. Path. and Bact. 59: 519, 1947. CrossrefMedlineGoogle Scholar13. Berlin R: Red cell survival studies in normal and leukemic subjects, Acta med. Scandinav., Supp. 252 139: 1951. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Washington, D. C.*Received for publication August 19, 1954.From the Department of Hematology, Army Medical Service Graduate School, Walter Reed Army Medical Center, and the Pulmonary Disease Division, District of Columbia General Hospital, Washington, D. C. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe Anemia of Inflammation and Chronic DiseaseAnemia of InfectionLiteraturverzeichnisDas BlutvolumenErythropoese und ErythrocytenumsatzErythropoese und ErythrocytenumsatzAutosomal dominant hemolytic anemia characterized by ovalocytosisHereditary elliptocytosis with hemolytic anemiaIron Kinetics in Laennec’s CirrhosisRed-Cell Lipids in Various Abnormalities of the Human Red CellMannitol InfusionInnere Erkrankungen mit latenter BlutumsatzsteigerungHypochromic Iron-loading Anaemia: Studies of Iron and Haenloglobin Metabolism by means of Vigorous PhlebotomySARCOIDOSIS: CLINICAL STAFF CONFERENCE AT THE NATIONAL INSTITUTES OF HEALTH*JOHN P. UTZ, M.D., EUGENE VAN SCOTT, M.D., HORACE W. BERNTON, M.D., JOHN H. EDGCOMB, M.D., JOSEPH J. BUNIM, M.D., NORMAN H. BELL, M.D., HERBERT E. KAUFMAN, M.D.The Use of the Isotope CR 51 for Studying Destruction of Red Cells in Healthy HumansTreatment of Haemochromatosis by Energetic Phlebotomy. One Patient's Response to the Letting of 55 Litres of Blood in 11 Months 1 April 1955Volume 42, Issue 4Page: 810-815KeywordsChromiumExcretionGraduate medical educationHematology and oncologyHemoglobinHemolytic anemiaMedical servicesPulmonary diseasesSodiumTuberculosis ePublished: 1 December 2008 Issue Published: 1 April 1955 PDF downloadLoading ...