Conformational preferences of the disubstituted 2,3-methanoamino acids DiFi and FiFi (illustrated here) have been probed. Specifically, this work describes syntheses of derivatives with two amide bonds (to mimic tripeptides), IR/CD spectroscopic studies of these, and elucidation of their solid-state X-ray structures. These experiments highlight the differences and similarities between these compounds and other phenyl-substituted cyclopropane amino acids.
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Moye-Sherman et al. (1999) studied this question.