Natural History of Symptomatic Cavernous Malformations and Results of Surgery

Yoshihisa Kida; Toshinori Hasegawa; Takenori Kato; Taku Sato; Hidemasa Nagai; Tomohito Hishikawa; Kenichiro Asano; Akira Kito

doi:10.7887/jcns.24.108

January 1, 2015Japanese Journal of NeurosurgeryOpen Access

Natural History of Symptomatic Cavernous Malformations and Results of Surgery

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Key Points

To delineate the natural history of symptomatic cerebral cavernous malformations and compare clinical outcomes between surgical resection and conservative management.
Multicenter questionnaire survey across major Japanese medical centers evaluating 78 symptomatic cavernous malformation cases (49 managed conservatively, 29 treated surgically).
Assessed progression-free survival via the Kaplan-Meier method, annual rebleeding rates pre- and post-event, and final functional outcomes.
Annual rebleeding rates in the conservative cohort reached 10.2% per year after a first hemorrhagic event and 19.7% per year after a second event.
Surgical intervention reduced the overall post-treatment rebleeding rate to 2.7% per year, whereas partial resection resulted in a rebleeding rate of 10.8% per year.
Final clinical functional outcomes did not significantly differ between conservative and surgical groups due to surgical invasiveness in deep locations such as the brainstem and basal ganglia.

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Implication

Multicenter survey reveals complete resection reduces rebleeding in symptomatic cavernous malformations, highlighting surgical risks in deep brain structures.

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Kida et al. (2015) studied this question.

synapsesocial.com/papers/6a9e55fe9465bdc041e985e6 https://doi.org/10.7887/jcns.24.108

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Natural History of Symptomatic Cavernous Malformations and Results of Surgery

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Implication

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Cite This Study

Natural History of Symptomatic Cavernous Malformations and Results of Surgery

Key Points

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Implication

Abstract

Discussion

Cite This Study

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