Nitrogen and Sulphur Metabolism in Bright's Disease

It has previously been noted by Peters and others1that patients exhibiting the nephrosis syndrome retain a large proportion of the intake of nitrogen without an increase in the nonprotein nitrogen in the blood, and that even when crystalline urea is added to the diet, it is retained. Peters and Van Slyke2thought that the retention of nitrogen serves to make up the loss of body protein chiefly in the form of albumin excreted in the urine. If this is true, it accounts in part for the retention of sulphur noted formerly.3So far as I have been able to ascertain, no studies have been made on the relation between the excretion of nitrogen and that of sulphur in this condition when crystalline urea has been added to a diet already high in protein. I shall report metabolism studies on a patient, whose case history was included