On the Maximum Production of Hippuric Acid in Animals With Consideration of the Origin of Glycocoll in the Animal Body

Parker and Luskl fed lithium benzoate to rabbits, with the object of ascertaining how much glycocoll the animals mayeliminate in the formation of hippuric acid.They also studied the relationship between the total nitrogen in the urine and the glycocoll (H.A.N).nitrogen eliminated as hippuric acid ~ N They found that for every 100 grams of total nitrogen excreted in the urine, an average of 4 grams of nitrogen was eliminated in the glycocoll radical of the hippuric acid.After administering the first large dose of lithium benzoate to the animals, they invariably obtained a much higher H* ^,' N' ratio; 9.01 per cent in experiment III, 7.14 per cent in experiment IV and 7,87 per cent in experiment VI.They regarded this as a "sweeping out of the surplus glycocoll" (in the sense of Wiene?).Since then Wiechowsk?and Magnus-Levy4 simultaneously, but independently, have studied the same problem.Wiechow-H.A.N.