Key result
Thrombosis-related gene polymorphisms (ABO, F5, MTHFR, and FGG) were not significantly associated with morbid obesity among European subjects (e.g., MTHFR TT vs CC OR 1.84; 95% CI 0.83-4.05; P=0.129).
Why the study?
Are thrombosis-related gene polymorphisms (ABO, F5, MTHFR, FGG) associated with morbid obesity in individuals of European descent?
Case-Control (n=623)
Are thrombosis-related gene polymorphisms (ABO, F5, MTHFR, FGG) associated with morbid obesity in individuals of European descent?
Thrombosis-related gene polymorphisms in ABO, F5, MTHFR, and FGG are not significantly associated with morbid obesity in individuals of European descent.
Answers are grounded in this paper and cite their sources.
No link between these polymorphisms and morbid obesity; leaves open other genetic contributors to thrombosis risk in this population.
Objective. Obesity is a well-known risk factor for thrombotic complications. The aim of the present study was to determine the frequency of thrombosis relatedABO,F5,MTHFR,andFGGgene polymorphisms in morbidly obese patients and compare them with the group of nonobese individuals.Methods. Gene polymorphisms were analyzed in 320 morbidly obese patients (BMI > 40 kg/m2) and 303 control individuals (BMI < 30 kg/m2) of European descent.ABOC>T (rs505922),F5C>G (rs6427196),MTHFRC>T (rs1801133), andFGGC>T (rs6536024) SNPs were genotyped by RT-PCR.Results. We observed a tendency forMTHFRrs1801133 TT genotype to be linked with morbid obesity when compared to CC genotype; however, the difference did not reach the significant P value (OR 1.84, 95% CI 0.83–4.05, P=0.129 ). Overall, the genotypes and alleles of rs505922, rs6427196, rs1801133, and rs6536024 SNPs had similar distribution between morbidly obese and nonobese control individuals. Distribution of height and weight means among individuals carrying different rs505922, rs6427196, rs1801133, and rs6536024 genotypes did not differ significantly.Conclusions. Gene polymorphismsABOC>T (rs505922),F5C>G (rs6427196),MTHFRC>T (rs1801133), andFGGC>T (rs6536024) were not associated with height, weight, or morbid obesity among European subjects.
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Kupčinskienė et al. (2016) conducted a case-control in Morbid obesity (n=623). Thrombosis-related ABO, F5, MTHFR, and FGG gene polymorphisms vs. Wild-type genotypes was evaluated on Morbid obesity (OR 1.84, 95% CI 0.83-4.05, p=0.129). Thrombosis-related gene polymorphisms (ABO, F5, MTHFR, and FGG) were not significantly associated with morbid obesity among European subjects (e.g., MTHFR TT vs CC OR 1.84; 95% CI 0.83-4.05; P=0.129).
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