Chiral Diselenides in Asymmetric Cyclization Reactions

This is the authors' abstract. We don't add key points for this paper.

The use of chiral selenium electrophile 6 generated in situ from the chiral diselenide 5 in asymmetric ring closure reactions of unsaturated alcohols, carboxylic acids and carbamates is presented herein. Tetrasubstituted carbon atoms can be generated selectively with diastereo-selectivities up to 85% when geminal disubstituted alkenes are used. The cyclization of vinylic silanes leads to versatile building blocks for further synthetic transformations.