that the total dosage of antimalarial drugs is related to toxicity,' it may well be correct, as suggested in Mackenzie's paper, that the true relation is with the daily dose, based on lean body mass.There is an important inference to be drawn from Mackenzie's work-that the normally recom- mended dosages may well be too high in either very slim people or very fat people.
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D. J. White (1995) studied this question.