In Drosophila melanogaster, the Notch locus has yielded both dominant and recessive mutants. The dominant Notch mutants are lethal in the hemizygous condition, while females heterozygous for Notch display notched wings, thickened wing veins and minor bristle abnormalities. Many Notch mutations are associated with deficiencies, inversions or translocations; however, an appreciable number of Notches are free of any cytological abnormality. The recessive mutants associated with this complex locus are (1) facet (fa), a rough eye mutant, (2) facet-notchoid (fano), a wing abnormality with a phenotype similar to that associated with the dominant Notches, (3) split (spl), a mutation which causes the eyes to be extremely rough and reduced in size and, in addition, results in certain bristle abnormalities, and (4) facet-notch (fan), the phenotypic expression of which is small nicks or notches in the wings. All these recessive visibles are viable and fertile in the homozygous and hemizygous condition,
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W J Welshons (1958) studied this question.