Extensive literature search and provision of summaries of studies related to the oral toxicity of perfluoroalkylated substances (PFASs), their precursors and potential replacements in experimental animals and humans. Area 1: Data on toxicokinetics (absorption, distribution, metabolism, excretion) in in vitro studies, experimental animals and humans. Area 2: Data on toxicity in experimental animals. Area 3: Data on observations in humans

Perfluoroalkylated substances (PFASs) have been widely used in many industrial applications such as textile, leather, carpet, paper and grease proofing treatments, surfactants, packaging materials, and fire-fighting foams. However, due to the persistence of perfluorooctane sulphonic acid (PFOS) and perfluorooctanoic acid (PFOA) in the environment and the human body their use has been phased out and replaced by other PFASs. Earlier risk assessments of PFOS and PFOA concluded that adverse health effects following exposure were unlikely, although the collection of additional exposure data was recommended. The overall objective of this project is to undertake an extensive literature search of the studies related to the oral toxicity of perfluoroalkylated substances (PFASs) in humans and experimental animals, their precursors and potential replacements, followed by a study selection for relevance, a critical appraisal of the quality of the relevant studies, and to provide descriptive summaries of these studies. In this report recent toxicity and epidemiology data are presented for PFASs, including data from studies in vitro, in experimental animals and in humans.