A decline in testicular function is recognized as a common occurrence in older men.However data are sparse regarding the effects of hypogonadism on age-associated physical and cognitive declines.This study was undertaken to examine the year-long effects of testosterone administration in this patient population.Fifteen hypogonadal men (mean age 68 Ϯ 6 yr) were randomly assigned to receive a placebo, and 17 hypogonadal men (mean age 65 Ϯ 7 yr) were randomly assigned to receive testosterone.Hypogonadism was defined as a bioavailable testosterone Ͻ60 ng/dL.The men received injections of placebo or 200 mg testosterone cypionate biweekly for 12 months.The main outcomes measured included grip strength, hemoglobin, prostate-specific antigen, leptin, and memory.Testosterone improved bilateral grip strength (P Ͻ 0.05 by
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R. Sih (1997) studied this question.
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