Seventy-four patients with glioblastoma multiforme were treated with radiotherapy; all but 5 also underwent prior craniotomy. The authors found that split-course treatments produced less favorable results than conventional fractionation, particularly when high doses were employed. Short-term survival was not improved by this approach. Total doses of 1,400-1,700 rets yielded the best survival rate.
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Aristizibal et al. (1971) studied this question.