Chiral N‐Fluorodibenzenesulfonimide Analogues for Enantioselective Electrophilic Fluorination and Oxidative Fluorination

This work describes the design, synthesis, and application of de novo chiral fluorinating agents as analogues of popular N‐fluorodibenzenesulfonimide (NFSI). The fluorination step by means of elemental fluorine is presented. Enantioselective fluorination is demonstrated in cyclic β‐keto esters and in the synthesis of BMS‐204352 (up to 86 % ee). Oxidative aminofluorination is also examined.