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Bioactive patterns: Green fluorescent protein has been immobilized with nanoscale resolution by streptavidin–biotin binding. High-resolution patterning of the protein on organosilane self-assembled monolayers can be achieved by electron beam lithography (see epifluorescence image). The technique produces protein nanoscale patterns with maintained bioactivity and high signal-to-noise ratio.
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Zhang et al. (2005) studied this question.
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