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January 1, 1980Chemistry Letters

Enantioface-Differentiating 1,4-Addition of Methyl Grignard Reagent to 1,3-Diphenyl-2-Propen-1-One

Tsuneo Imamoto Teruaki Mukaiyama

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Abstract

A good optical yield (68%) was achieved in the title reaction in the presence of (S)-1-methyl-2-hydroxymethylpyrrolidine as the chiral ligand.

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Cite This Study

Imamoto et al. (1980) studied this question.

synapsesocial.com/papers/6a9e676a0f4f904a46acb78d https://doi.org/10.1246/cl.1980.45

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Asymmetric syntheses using tert-leucine. 1. An asymmetric synthesis of .beta.-substituted aldehydes via 1,4-addition of Grignard reagents to chiral .alpha.,.beta.-unsaturated aldiminesOriginal Research · 1976 · 74 citations
2The Synthetic Utility of 2‐OxazolinesOriginal Research · 1976 · 174 citations
3Asymmetric Synthesis Based on (2R,3S)-3,4-Dimethyl-2-phenylperhydro-1,4-oxazepine-5,7-dione. Synthesis of Highly Optically Active β-Substituted Alkanoic AcidsOriginal Research · 1978 · 80 citations
41,4-Addition of organometallic reagents to .alpha.,.beta.-unsaturated ketones in the presence of (-)-sparteineOriginal Research · 1972 · 73 citations
5Enantioface-differentiating (asymmetric) addition of alkyllithium and dialkylmagnesium to aldehydes by using (2S,2'S)-2-hydroxymethyl-1-[(1-alkylpyrrolidin-2-yl)methyl]pyrrolidines as chiral ligandsOriginal Research · 1979 · 255 citations

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