Amino Terminal Pro-B-Type Natriuretic Peptide and Late Left Ventricular Reverse Remodeling in Coronary Artery Bypass Grafting Patients with Low Ejection Fraction

Objective: Left ventricular remodeling accelerates the course of cardiac failure by aggravating ventricular dysfunction following myocardial infarction. Thus, prediction and prevention of left ventricular remodeling is crucial. The aim of this study was to evaluate the predictive value of perioperative plasma NT-proBNP levels for postoperative left ventricular reverse remodeling and ejection fraction in patients who underwent coronary artery bypass grafting. Material and Methods: Forty patients with myocardial infarction inprevious three months were enrolled in the study. All patients with moderate left ventricular dysfunction (EF 40%) underwent on pump coronary artery bypass grafting (CABG) operation. Patients' preoperative left ventricle volumes and indexes, ejection fractions, and NT-proBNP levels were compared to the postoperative values. Results: Preoperative NT-proBNP levels were significantly related to preoperative and postoperative ejection fractions, and postoperative left ventricular reverse remodeling (p= 0.037, p= 0.033, p= 0.014, respectively). Conclusion: The preoperative N-terminal proBNP may help to assess the postoperative ejection fraction and ventricular remodeling. Amino terminal proBNP is a safe, available and effective tool to predict the postoperative functional and structural changes of the left ventricle.