Key result
Inhalation of cigarette smoke in conscious dogs increased minute ventilation from a baseline of 3.2 to a peak of 23.9 l/min, mediated by vagal afferents and carotid body chemoreceptors.
Absolute Event Rate: 23.9% vs 3.2%
In conscious dogs, the initial respiratory response to cigarette smoke is mediated by vagal afferents, while the delayed hyperpnea is primarily driven by carotid body chemoreceptors.
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May guide mechanistic studies of smoke reflexes; leaves open translation to human tobacco exposure responses.
Lee et al. (1983) studied this question. Inhalation of cigarette smoke vs. Base line was evaluated on Minute ventilation (VE). Inhalation of cigarette smoke in conscious dogs increased minute ventilation from a baseline of 3.2 to a peak of 23.9 l/min, mediated by vagal afferents and carotid body chemoreceptors.
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