Hepatocyte-matrix interactions.

Hepatocyte-matrix interactionsThe normal hepatic sinusoid consists of a fenestrated endothelial capillary, behind which, and adjacent to the border of the hepatic pallisade, is the space of Disse.This term is in some respects a misnomer, for within it are the hepatic lipocytes (fat storing or Ito cells) and a specialised basement membrane-like matrix, which consists predomi- nantly of type IV collagen, laminin, and proteoglycans.Extracellular matrix is an integral part of multicellular organisms, providing structural integrity and support to cells.Current evidence indicates that matrix is not merely a simple scaffolding but a dynamic modulator of cell pheno- type and behaviour.There is now evidence that the basement membrane-like matrix of the liver can change the phenotypic characteristics and growth of lipocytes, endothelial cells, and hepatocytes.4Recent developments in matrix biochemistry and cell biology have offered a fascinating insight into the complex interaction of hepatocytes and their surrounding matrix in both health and disease.The importance of extracellular matrix was first appreciated in hepatocyte culture studies.