July 23, 2009Angewandte Chemie

Palladium(II)‐Catalyzed Regioselective Direct C2 Alkenylation of Indoles and Pyrroles Assisted by the N‐(2‐Pyridyl)sulfonyl Protecting Group

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AGAlfonso García‐RubiaCentro de Investigaciones Biológicas Margarita Salas RARamón Goméz ArrayásInstitute of Advanced Chemistry of Catalonia JCJuan C. CarreteroInstitute of Advanced Chemistry of Catalonia

Abstract

Leicht hin, leicht weg: In Gegenwart der N-(2-Pyridyl)sulfonylgruppe gelingt die direkte PdII-katalysierte Alkenylierung von Indolen an C2 in guten Ausbeuten (siehe Schema, DMA=Dimethylacetamid). Das Protokoll wurde auf Pyrrolderivate erweitert. Eine anschließende reduktive Desulfonylierung lieferte die C2-substituierten Indole und Pyrrole ebenfalls in guten Ausbeuten.

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García‐Rubia et al. (2009) studied this question.

synapsesocial.com/papers/6a9e6aeff835b2283e37fcae https://doi.org/10.1002/ange.200902802

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Palladium(II)‐Catalyzed Regioselective Direct C2 Alkenylation of Indoles and Pyrroles Assisted by the N‐(2‐Pyridyl)sulfonyl Protecting Group

Abstract

Discussion

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Cite This Study

Palladium(II)‐Catalyzed Regioselective Direct C2 Alkenylation of Indoles and Pyrroles Assisted by the N‐(2‐Pyridyl)sulfonyl Protecting Group

Abstract

Discussion

Member takes

Cite This Study

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