Key result
Early physiological pregnancy was associated with a significantly decreased 24-hour mean of sinus R-R intervals and entropy compared to non-pregnant women.
Why the study?
Does early physiological pregnancy alter the circadian rhythm and entropy of sinus R-R intervals compared to non-pregnant women?
Observational (n=20)
Does early physiological pregnancy alter the circadian rhythm and entropy of sinus R-R intervals compared to non-pregnant women?
Early pregnancy is associated with a reduction in the deterministic periodic chaos of heart rate variability, suggesting a tonic elevation of sympathetic activity regulating cardiac pacing.
Answers are grounded in this paper and cite their sources.
HRV reductions in early pregnancy warrant no practice change; leaves open prospective links to arrhythmia or outcome risk.
The study estimates the unpredictable disorder (chaos) within the 24 h pattern of sinus R-R intervals (SRRI) in clinically healthy pregnant women (CHPW) and clinically healthy non-pregnant women (CHNPW), in order to evaluate the early gestational changes in neurovegetative cardiac pacing. SRRI were provided by the 24-h Holter ECG of 10 CHPW and 10 CHNPW. SRRI were investigated by descriptive conventional statistics by means of the Time and Frequency Domain Analysis, and subsequently, in their chaotic component by means of entropy analysis. Both the SRRI and entropy were tested via the Cosinor method to better decipher whether or not the periodic disorder in heart rate variability is modified in pregnancy as a result of a gestational tonic resetting of the cardiac sympatho-vagal regulation. Cosinor analysis documented that the circadian rhythm of both the SRRI and entropy were preserved in CHNPW and CHPW. However, the circadian rhythm of SRRI and entropy in CHPW exhibited a significantly decreased 24 h mean. Via the analysis of the rhythmicity of entropy, this study has documented that the chaos in the 24 h pattern of SRRI is less prominent in CHPW than in CHNPW. Such a reduction of level in the deterministic periodic chaos of heart rate variability provides evidence that, in early pregnancy, a tonic elevation of the sympathetic activity regulates cardiac pacing.
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Curione et al. (2005) conducted an observational in Early physiological pregnancy (n=20). Early physiological pregnancy vs. Clinically healthy non-pregnant women was evaluated on Circadian rhythm of sinus R-R intervals (SRRI) and entropy. Early physiological pregnancy was associated with a significantly decreased 24-hour mean of sinus R-R intervals and entropy compared to non-pregnant women.
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