Key result
Intravenous dihydropyridine calcium channel blockers are increasingly used as antihypertensive and vasodilatory agents in the perioperative setting of coronary artery bypass graft surgery.
Intravenous dihydropyridine calcium channel blockers are increasingly used as antihypertensive and vasodilatory agents in the perioperative setting of CABG surgery due to their lack of negative inotropic and chronotropic effects.
Rising CABG perioperative use warrants outcome surveillance; leaves open need for RCTs to define safety and efficacy.
The pharmacology characteristics of dihydropyridine calcium channel blockers (CCB) make them an attractive antihypertensive medication for use in the perioperative setting of coronary artery bypass graft (CABG) surgery. They lack the negative inotropic, negative chronotropic, and negative bathmotropic effects of phenylalkylamine and benzothiazepine CCB that limit the use in patients with heart failure or patients with bradyarrythmias. With the aging population and significant rise in the prevalence of heart failure, the use of dihydropyridine CCB as antihypertensive medication after CABG surgery has become more common. Furthermore, intravenous dihydropyridine CCB are being used in the perioperative setting as vasodilatory agents after radial artery harvesting for total arterial coronary revascularization. We review the pharmacological effects of intravenous dihydropyridine CCB, analyze the literature, and comment on the consequences in modern clinical practice.
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Khoynezhad et al. (2008) conducted a review in Patients undergoing coronary artery bypass graft (CABG) surgery. Intravenous dihydropyridine calcium channel blockers was evaluated. Intravenous dihydropyridine calcium channel blockers are increasingly used as antihypertensive and vasodilatory agents in the perioperative setting of coronary artery bypass graft surgery.
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