In this paper we report a method of semiquantitative process screening or route scouting developed to reduce the number of potential process flowsheets for a multistep biocatalytic conversion. Using the dual-enzyme-based synthesis of d -xylulose- 5-phosphate as a model, a variety of possible processes was identified. Using data from a limited number of key experiments describing important process attributes, a screening procedure was proposed. Unattractive processes were eliminated early, and the best candidates were put forward as potential options for subsequent development. The method should prove applicable to a range of process synthesis problems.
No takes yet. Share an insight, caveat, or question.
Shaeri et al. (2006) studied this question.