Our failure, so far, to obtain positive effects after in vivo injection of mouse tumor fractions was attributed to the relative weakness of the tumor fraction rather than to the presence of two different agents in the tumor-one that would be responsible for the in vivo effects and one responsible for the in vitro effects.The present finding that the much stronger venom factor reproduces both effects in every detail gives further strong support to our contention.
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Wangersky et al. (1956) studied this question.
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