Comparative molecular analysis reveals distinct chromosomal patterns and gene locations in pathogenic versus nonpathogenic Entamoeba histolytica strains, highlighting extensive genomic divergence.
The electrophoretic karyotypes of a pathogenic and a nonpathogenic strain of Entamoeba histolytica were determined by pulsed-field gel electrophoresis. A number of previously isolated genes were assigned to specific chromosomal bands. Significant differences between the chromosomal patterns of these strains as well as in the assignment of most genes were found.
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Petter et al. (1993) studied this question.
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