Key result
The High-STEACS early rule-out pathway using high-sensitivity cardiac troponin T identified low-risk patients with an NPV of 99.3% (95% CI 98.8-99.7%) and sensitivity of 97.1%.
Observational
Effect estimate: NPV 99.3% (95% CI 98.8 to 99.7)
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Supports safe early rule-out of ACS with hs-cTnT pathway in practice; extends prior RCT findings to broader observational populations.
Chapman et al. (2020) conducted an observational in Suspected acute coronary syndrome. High-STEACS early rule-out pathway using high-sensitivity cardiac troponin T assay vs. Guideline-recommended approaches using the 99th centile was evaluated on Negative predictive value for early rule-out (NPV 99.3%, 95% CI 98.8 to 99.7). The High-STEACS early rule-out pathway using high-sensitivity cardiac troponin T identified low-risk patients with an NPV of 99.3% (95% CI 98.8-99.7%) and sensitivity of 97.1%.
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