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Split into seven sizes: Highly ordered cleavage of supercoiled plasmid DNA by S1 nuclease was accomplished through DNA complexation with water-soluble cationic block copolymers (see schematic representation). The results provide insights into the mechanisms of endogenous protein-induced modification of DNA and into the design of artificial restriction enzymes through the supramolecular assembly of synthetic macromolecules.
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Osada et al. (2005) studied this question.
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