December 1, 1990The Journal of Clinical Pharmacology
Effect of Phenytoin on the Clinical Pharmacokinetics of Amiodarone
Why the study?
Does co-administration of phenytoin alter the pharmacokinetics of amiodarone in healthy volunteers?
Population
5 healthy male volunteers
Comparison
Oral amiodarone hydrochloride 200 mg/day for 6.5… vs Predicted amiodarone serum concentrations based…
Design
Cohort
Follow-up
6.5 weeks
Authors
Discussion
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Implication
May warrant amiodarone level monitoring with phenytoin; leaves open confirmation and dosing guidance in patients.
Structured PICO
Does co-administration of phenytoin alter the pharmacokinetics of amiodarone in healthy volunteers?
P
Population
5 healthy male volunteers
I
Intervention
Oral amiodarone hydrochloride 200 mg/day for 6.5 weeks, with co-administration of oral phenytoin 2-4 mg/kg/day during weeks 5-6
C
Comparator
Predicted amiodarone serum concentrations based on pre-phenytoin administration (weeks 2-4)
O
Outcome
Amiodarone serum concentrations (ASC) and N-desethylamiodarone serum concentrations (DEASC)surrogate
Co-administration of phenytoin significantly decreases amiodarone serum concentrations, likely due to induction of amiodarone metabolism.
Cite This Study
Nolan et al. (1990) studied this question.