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What are the in vivo nail-fold capillary alterations during hemorrhagic fever compared to other infectious illnesses?
What are the in vivo nail-fold capillary alterations during hemorrhagic fever compared to other infectious illnesses?
Hemorrhagic fever is characterized by profound, generalized capillary dysfunction, including marked dilatation and decreased vasomotor activity during the hypotensive phase, which correlates with clinical severity.
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Capillary changes may contribute to hypotension in hemorrhagic fever; hypothesis-generating and requires prospective validation before clinical consideration.
This report describes the changes detected during serial observations of the nail-fold capillary bed of such patients with hemorrhagic fever. The capillary alterations observed in patients with other infectious diseases who were studied in a similar manner are also described. The findings indicate that significant alterations of the capillary vessels may be observed directly during hemorrhagic fever and during certain other infectious illnesses, and that these capillary alterations can be correlated with the clinical course and pathological findings.
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Sheldon E. Greisman (1957) studied this question.
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