Remission rate of patients with wheat allergy sensitized to hydrolyzed wheat protein in facial soap

Remission rate of patients with wheat allergy sensitized to hydrolyzed wheat protein in facial soap Dear Editor, Hydrolyzed wheat protein (HWP) is made from gluten by acid or enzyme modification and used for many cosmetics around the world.Recently, reports emerged about 2169 patients with wheat allergy sensitized to HWP in facial soap (HWP-wheat allergy) and consequently represented in an important social problem in Japan.1e3 Most patients had used the same soap bar named "Cha-no-Shi-zuku™" containing HWP. HWP used in "Cha-no-Shizuku™" was Glupearl 19S.Although it was also contained in several other types of soap bars, all of them had already been recalled.Most of the patients sensitized to HWP were female and their peak age was in the 40s. 3 Several severe cases led to anaphylaxis.56% and 16% of the patients developed symptoms after exercise or oral intake of NSAIDs, respectively.Although serum wheat-and gluten-specific IgE are negative and Peer review under responsibility of Japanese Society of Allergology.