Key result
Repeat extracorporeal membrane oxygenation was associated with similar 30-day postdischarge survival (50% vs 48.3%; P=NS) and in-hospital mortality (50% vs 50%) as single ECMO.
Why the study?
Does repeat ECMO support result in similar mortality outcomes compared to single ECMO support in patients requiring ECMO?
Cohort (n=246)
Does repeat ECMO support result in similar mortality outcomes compared to single ECMO support in patients requiring ECMO?
Repeat ECMO patients have similar mortality and 30-day survival outcomes compared to the overall ECMO population, suggesting repeat ECMO is a viable clinical option.
Answers are grounded in this paper and cite their sources.
Repeat ECMO appears feasible in select patients; leaves open multicenter prospective data on outcomes and selection.
BACKGROUND: As the number of patients requiring extracorporeal membrane oxygenation (ECMO) increases nationwide, many patients may require ECMO more than once. We review our experience and outcomes in patients requiring repeat ECMO support. METHODS: The Nebraska ECMO Research Database was utilized for data analysis, and repeat ECMO patients (REPs) were compared to the overall ECMO population. RESULTS: Of 246 patients, 2.4% (6/246) were REPs. There was no statistical difference between the median days of initial support run (P = 0.670) and second support run (P = 0.813) for REPs when comparing to the non-REP population. Median hospital length of stay for REPs was 53 days (16-124) compared to the non-REPs, who had a median hospital length of stay of 22 days (1-270); P = 0.043. In-hospital mortality rate for REPs was 50% (3/6) and 50% for non-REPs (120/240). Survival 30 days postdischarge for REPs was 50% (3/6) compared to non-REPs at 48.3% (116/240); P = NS. CONCLUSIONS: Outcomes for repeat ECMO patients compare favorably to the overall ECMO population and suggest a need to explore and broaden the clinical indications for repeat ECMO.
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Brady et al. (2018) conducted a cohort in Extracorporeal membrane oxygenation (ECMO) requirement (n=246). Repeat extracorporeal membrane oxygenation (ECMO) vs. Single ECMO support was evaluated on Survival 30 days postdischarge (p=NS). Repeat extracorporeal membrane oxygenation was associated with similar 30-day postdischarge survival (50% vs 48.3%; P=NS) and in-hospital mortality (50% vs 50%) as single ECMO.
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