Enantiomerically pure (+)-(2S,6R)-2-propyl-6-methyl-piperidine 6 has been obtained in 4 steps, 66% overall yield and without separation of diastereomers from the chiral 2-cyano-6-oxazolopiperidine synthon 1c derived from (+)-1,2-diphenyl-2-aminoethanol
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Theodorakis et al. (1991) studied this question.
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