Mitomycin C Extravasation Exacerbated by Sunlight

Letters and Corrections1 April 1981Mitomycin C Extravasation Exacerbated by SunlightBARBARA FULLER, M.D., MARY LIND, M.A., PHILIP BONOMI, M.D.BARBARA FULLER, M.D.Search for more papers by this author, MARY LIND, M.A.Search for more papers by this author, PHILIP BONOMI, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-94-4-542_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Mitomycin C, an antitumor antibiotic, is active in numerous tumors (1) and is being used with increasing frequency in the treatment of gastric carcinoma (2). The risks of mitomycin C treatment include subcutaneous extravasation resulting in local tissue necrosis several weeks later (3). We describe a case in which prolonged exposure to sunlight appears to have caused cutaneous ulceration 3 months after mitomycin C extravasation.A 51-year-old man who had undergone a left hemicolectomy on 8 November 1978 for carcinoma of the colon began receiving mitomycin C for hepatic metastases in April 1980. On 5 May 1980...References1. CROOKEBRADNER SW. Mitomycin-C: a review. Cancer Treat Rev. 1976;3:121-39. CrossrefMedlineGoogle Scholar2. MACDONALDWOOLLEYSMYTHEVUNOHOTHSCHEIN JPTWDP. 5-fluorouracil, adriamycin, mitomycin-C (FAM) combination chemotherapy in the treatment of advanced gastric cancer. Cancer. 1979;44:42-7. CrossrefMedlineGoogle Scholar3. IGNOFFOFRIEDMAN RM. Therapy of local toxicities caused by extravasation of cancer chemotherapeutic drugs. Cancer Treat Rev. 1980;7:17-27. CrossrefMedlineGoogle Scholar4. SOKOLOFFFUJISAWAENOMOTO BMK. Experimental studies on mitomycin C: 2. Cytotoxicity. Growth. 1960;24:1-27. MedlineGoogle Scholar5. LUEDKEKENNEDYRIETSCHEL APR. Histopathogenesis of skin and subcutaneous injury by adriamycin. Plast Reconstruct Surg. 1979;63:463-5. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Rush University Chicago, IL 60612 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByDrug ReactionsMitomycin CMitomycin CMitomycin CDelayed Tissue Necrosis Associated with Mitomycin-C AdministrationDistant and Delayed Mitomycin C ExtravasationDelayed-type sensitivity reaction to mitomycinTreatment methods for extravasations of chemotherapeutic agents: A comparative studyLocal erythema multiforme-like drug reaction following intravenous mitomycin C and 5-fluorouracilCutaneous complications of chemotherapeutic agentsCytostatic and immunosuppressive drugsMitomycin C (z.B. Mitomycin C „Kyowa“) 1 April 1981Volume 94, Issue 4_Part_1Page: 542-542KeywordsAntibioticsColectomyColonNecrosisUlcers Issue Published: 1 April 1981 PDF DownloadLoading ...