Key result
Ectopic expression of Yes-associated protein 1 (Yap1) decreased the stability of DeltaNp63alpha, resulting in its ubiquitin-dependent degradation.
Yap1 physically interacts with and regulates the stability and ubiquitin-dependent degradation of DeltaNp63alpha.
No immediate clinical implications; leaves open Yap1-p63 roles in cardiac regeneration pending mammalian validation.
Regulation of DeltaNp63alpha can be achieved at the transcriptional and post-translational levels, with the latter being greatly influenced by external stimuli such as DNA damaging agents. In this present study, we demonstrated that DeltaNp63alpha physical interacts with Yes-associated protein 1 (Yap1). Ectopic expression of Yap1 decreased the stability and the half-like of DeltaNp63alpha and resulted in ubiquitin-dependent degradation of DeltaNp63alpha. Further, the cisplatin mediated degradation of DeltaNp63alpha is attenuated with the downregulation of Yap1. Thus, our results strongly suggest that Yap1 plays a role in the regulation of endogenous DeltaNp63alpha levels and is likely to contribute to the regulation of DeltaNp63alpha, in physiological conditions.
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Chatterjee et al. (2010) studied this question. Yes-associated protein 1 (Yap1) ectopic expression was evaluated on DeltaNp63alpha stability and degradation. Ectopic expression of Yes-associated protein 1 (Yap1) decreased the stability of DeltaNp63alpha, resulting in its ubiquitin-dependent degradation.
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