Chiral monomers 1 and 2, carrying C4- and C3-symmetric bowl-shape peptidic macrocycle cores, respectively, undergo supramolecular polymerization in solution via van der Waals and hydrogen bonding interactions. Size-exclusion chromatographic studies, using UV and CD detectors, on the supramolecular copolymerization of their enantiomers demonstrated that these monomers are the first chiral macrocycles that polymerize enantioselectively with a strong preference for chiral self-sorting.
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Sato et al. (2013) studied this question.
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