Ameliorative Effects of Lonicera japonica Extract on Scopolamine-Induced Memory Deficits via Cholinergic Modulation

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by memory and learning decline leading to dementia. Lonicera japonica (LJ), traditionally used in East Asian medicine, has shown various pharmacological effects including anti-inflammatory, antioxidant, and antimicrobial activities. Previous studies demonstrated that LJ extract protects HT22 neuronal cells against glutamate-induced neurotoxicity. In this study, we examined the cognitive-enhancing effects of LJ using a scopolamine-induced memory impairment model in mice. Spatial and associative learning were assessed using the Morris water maze and passive avoidance tests, respectively. LJ extract was prepared via ultrasonic methanolic extraction and administered orally at 100, 200, and 300 mg/kg body weight. Results showed that LJ significantly improved scopolamine-induced memory deficits and inhibited acetylcholinesterase activity. These findings suggest that LJ may enhance cognitive function through modulation of the cholinergic system and support its potential as a candidate for nutraceutical development targeting memory impairment.