Tuberculous meningitis with tuberculomata presenting as postpartum pyrexia of unknown origin

A35-year-old Chinese woman had primary infertility as a result of bilateral fallopian tube blockage. She had had uterine fibroids resected 3 years previously. Her precious pregnancy via in-vitro fertilization was complicated by premature rupture of amniotic membrane at 18 weeks' gestation. Two doses of betamethasone 12 mg were given at 29 weeks' gestation, and fetal bradycardia was noted on the next day. A baby girl was delivered by emergency caesarean section. The patient had a high swinging fever following the delivery. Extensive investigations for postpartum pyrexia were normal or negative. She was given courses of broad-spectrum antibiotics for 4 weeks before she developed mental dullness and right partial ptosis. On the next day, she became disorientated with left hemiplegia. Examination also revealed left-sided neglect, dysphasia, conjugate gaze deviation to the right, and left homonymous hemianopia. Computed tomography (CT) of the brain revealed a left temporal hypodense area (Figure 1a). Lumbar puncture revealed the following CSF findings: opening pressure of 34 cmH 2 O, protein level of 3.8 g/litre, glucose level of 2.1 mM (serum 6.4 mM), cell count of 30 × 10 6 /litre (56% lymphocytes, 40% neutrophils, 4% monocytes), and red cell count of 11 × 106/litre. Other CSF tests were negative.