The acyl group attached to the antitumor active polysaccharide (GE-3) isolated from G. esculenta has been identified as O-acetyl, and the content was determined to be about 2%. The O-acetyl groups were located in the 3-position of the glucose units by employing the method of Bouveng. The molecular weight of the polysaccharide was calculated to be approximately 20000 by equilibrium ultracentrifugation. The antitumor effects of some derivatives of GE-3 were tested against the implanted sarcoma-180. The results suggested that the O-acetyl groups are concerned in the antitumor activity. The identity of the polysaccharide isolated from L. papulosa with GE-3 has been further extended, since the acyl group attached to the former was also proved to be O-acetyl.
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Nishikawa et al. (1969) studied this question.
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