14-3-3η Cytokine as a New Rheumatoid Arthritis Activity Assessing Biomarker

This is the authors' abstract. We don't add key points for this paper.

Currently, rheumatoid arthritis routine diagnosis includes joint syndrome indicator determination such as tender and swollen joints count, as well as a number of laboratory indicators. The most interesting are the second ones, which include rheumatoid factor, antibodies to cyclic citrullinated peptide and a some acute-phase indicators, but they have low sensitivity and specificity, especially in the disease early stages, when it is still possible to normalize bring the age-norm indicators and get stable disease remission. Additionally, some of these medical tests are expensive enough and compulsory health insurance not-included. But, most importantly, there are no reliable rheumatologist modern practice disease activity assessing tools depending on the current-used treatment strategy. The article evaluates 14-3-3η protein usage possibility as a promising biomarker for rheumatoid arthritis immuno-inflammatory process activity in joints assessment. It was shown a higher studied indicator informative value (in terms of accuracy, sensitivity, specificity) in comparison with traditional acute-phase indicators, such as the erythrocyte sedimentation rate and C-reactive protein.