A study on the stimulative and inhibitory effects of low incident power densities of argon laser energy on wound healing in rats was undertaken. Our results were calculated at 80% of wound closure relative to control showed acceleration in healing days and size reduction were 22.9% and 41.9%, respectively, at the maximum stimulative dose of approximately 19 J/cm2, and 8 J/cm2 and -8.7% -14.8% at the optimum inhibitory dose of approximately 130 J/cm2 for an elliptical (0.39 cm2) wound size with 3 times/week treatment schedule in 27 weeks old rats; doses of approximately 80 J/cm2 showed zero bioactivation. Statistical analysis with the student’s t-test revealed significant differences between irradiated and unirradiated control wounds with dose variations up to 60 J/cm2 and insignificant differences at higher doses. Wound acceleration was dose-dependent, increasing with the incident dose until it reached maximum, whereafter the stimulation effect disappeared and inhibition increased up to the maximum dose of around 130 J/cm2. Calculated skin reflection losses in the region of 70% required higher dosages to detect this phenomenon. There was no appreciable temperature rise up to doses of 150 J/cm2 for a power density of 80 mW/cm2. Reduced effectiveness of wound shape and size were also noted at the higher inhibitory doses.
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A.H. et al. (1995) studied this question.