The nexus of NEXIS – underscoring the need for rehabilitation for the critically ill patient

Q: What does this research mean for the field?

Rehabilitation is a necessary and critical component of care for critically ill patients. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

Michelle E. Kho; Rik Gosselink

doi:10.1093/ajrccm/aamag455

September 4, 2026American Journal of Respiratory and Critical Care MedicineOpen Access

The nexus of NEXIS – underscoring the need for rehabilitation for the critically ill patient

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Key Points

To underscore the necessity of targeted physical rehabilitation and supportive interventions for patients experiencing critical illness.
Expert editorial and clinical commentary contextualizing the NEXIS trial framework.
Narrative synthesis addressing early exercise, mobility protocols, and post-intensive care functional recovery.
Severe critical illness and bed rest lead to rapid muscle wasting and prolonged physical impairment.
Early implementation of structured rehabilitation alongside medical care is essential to mitigate intensive care unit-acquired weakness and support long-term recovery.

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Implication

Commentary highlights the need for rehabilitation in critically ill patients, emphasizing early mobility interventions to improve functional recovery.

Abstract

Michelle E Kho, Rik Gosselink; The nexus of NEXIS – underscoring the need for rehabilitation for the critically ill patient, American Journal of Respirator

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Cite This Study

Kho et al. (2026) studied this question.

synapsesocial.com/papers/6a9e8559c3034f961570d784 https://doi.org/10.1093/ajrccm/aamag455

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The nexus of NEXIS – underscoring the need for rehabilitation for the critically ill patient

Key Points

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Implication

Abstract

Discussion

Cite This Study

The nexus of NEXIS – underscoring the need for rehabilitation for the critically ill patient

Key Points

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Implication

Abstract

Discussion

Cite This Study

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