Differential prognosis impact of IDH2 mutations in cytogenetically normal acute myeloid leukemia

To the editor: Mutations in the genes isocitrate dehydrogenase 1 and 2 ( IDH1/IDH2 ) have been recently identified in gliomas and acute myeloid leukemia (AML).[1][1] We and others reported that IDH1 R132 mutations were associated with normal karyotype and nucleophosmin 1 gene ( NPM1 ) mutations. In