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Objective: This article systematically reviewed intervention strategies for cancer-related sarcopenia (CRS), providing evidence for researchers to develop targeted treatments. Methods: PubMed, Embase, Web of Science, and the Cochrane Library were searched for studies between 2015 and 2025, followed by literature screening and content analysis. Results: A total of 3,566 articles were initially identified, and 18 randomized controlled trials (published between 2016 and 2025; sample sizes ranging from 15 to 232) were ultimately included. CRS interventions were categorized into four types: nutritional, exercise, pharmacological, and multidisciplinary. Conclusion: A CRS intervention needs an integrated approach that combines nutrition, exercise, pharmacology, and a multidisciplinary team (MDT) to improve patients' functional outcomes and quality of life. Future research should focus on precision approaches and translational medicine.
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Li et al. (2025) studied this question.
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