The α2‐adrenergic receptor antagonist atipamezole has been labelled with carbon‐11 using [11C]formaldehyde and 2‐ethyl‐2‐oxoacetylindane. Various routes are proposed for the synthesis of the latter: oxidation of 2‐acetyl‐2‐ethylindane, hydrolysis of 2‐diethoxy‐2‐indane and oxidation of 2‐diazoacetyl‐2‐ethylindane. The average radiochemical yield of [11C]atipamezole was 24% based on [11C]formaldehyde, and the synthesis time, including HPLC purification and formulation, was 45 min.
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Roeda et al. (2001) studied this question.
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